Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORA | P35398 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.52 |
| ▸ | RORB | Q92753 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13983677 | 0.86 | RORA (0.48) | RORARORCRORBLCKPIK3CG | |
| SCHEMBL4378568 | 0.84 | ALDH1A1 (0.43) | RORARORCRORBLCKKDM4E | |
| SCHEMBL6027221 | 0.77 | RORA (0.55) | RORARORCRORBPIK3CGPIK3CD | |
| SCHEMBL12197706 | 0.75 | RORA (0.54) | RORARORCRORBLCKPIK3CG | |
| SCHEMBL4384160 | 0.74 | HSD11B1 (0.51) | KDM4E | |
| SCHEMBL2959779 | 0.73 | RORA (0.69) | RORARORCRORBPIK3CGPIK3CD | |
| SCHEMBL10125972 | 0.72 | PIK3CG (0.57) | RORARORCRORBLCKPIK3CG | |
| SCHEMBL41794 | 0.72 | PIK3CG (0.59) | RORARORCRORBLCKPIK3CG | |
| SCHEMBL4854398 | 0.72 | PIK3CG (0.50) | RORARORCRORBLCKPIK3CG | |
| SCHEMBL12201045 | 0.71 | RORA (0.51) | RORARORCRORBLCKPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893609-B1 | N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES | PFIZER (US) | 2009-11-18 | — | — | EP | disclosed |
| US-7462634-B2 | N-(pyridin-2-yl)-sulfonamide derivatives | AGOURON PHARMACEUTICALS, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| EP-1893609-A1 | N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES | Pfizer, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| US-20070072914-A1 | N-(pyridin-2-yl)-sulfonamide derivatives | AGOURON PHARMACEUTICALS, INC. | 2007-03-29 | — | — | US | disclosed |
| WO-2006134467-A1 | N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES | PFIZER INC. (US) | 2006-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072914-A1 | N-(pyridin-2-yl)-sulfonamide derivatives | HSD11B1, HSD3B1, HSD11B2 | RORA 151/4885RORC 282/4885RORB 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.