Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 7/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2868617 | 0.78 | MAPK10 (0.58) | ITKAURKAAURKBLRRK2MAPK10 | |
| SCHEMBL13635414 | 0.77 | MAPK10 (0.44) | ITKMAPK10 | |
| SCHEMBL13635739 | 0.69 | MAPK10 (0.38) | ITKAURKAAURKBMAPK10TTK | |
| SCHEMBL27539189 | 0.65 | CLK2 (0.44) | ITKAURKAAURKBLRRK2KDM4E | |
| SCHEMBL2867353 | 0.65 | ITK (0.60) | ITKAURKAAURKBLRRK2TTK | |
| SCHEMBL5383308 | 0.64 | KMT2A (0.56) | AURKAAURKBTTK | |
| SCHEMBL2866702 | 0.63 | MAPK10 (0.44) | ITKKDM4EMAPK10 | |
| SCHEMBL5415164 | 0.63 | ROCK2 (0.63) | — | |
| SCHEMBL16025730 | 0.62 | LRRK2 (0.55) | LRRK2MAPK10 | |
| SCHEMBL2867196 | 0.62 | MAPT (0.64) | ITKAURKAAURKBLRRK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |