Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473754 | 0.89 | MAPK14 (0.55) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL13635755 | 0.82 | ALDH1A1 (0.56) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL4376114 | 0.80 | MAPK14 (0.64) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL3520420 | 0.75 | MAPK14 (0.48) | POLBTHRBMAPK14KDM4ELMNA | |
| SCHEMBL13635888 | 0.72 | L3MBTL1 (0.50) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL4474073 | 0.72 | MAPK14 (0.57) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL4376180 | 0.72 | MAPK14 (0.51) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL4374297 | 0.71 | MAPK14 (0.52) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL4389631 | 0.70 | ALDH1A1 (0.55) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL4381707 | 0.67 | MAPK14 (0.77) | POLBTHRBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |