Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | DBH | P09172 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | CLPP | Q16740 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389631 | 0.87 | ALDH1A1 (0.55) | ALDH1A1KDM4EL3MBTL1MAPK14POLB | |
| SCHEMBL13635320 | 0.82 | POLB (0.49) | ALDH1A1KDM4EL3MBTL1MAPK14POLB | |
| SCHEMBL4474073 | 0.81 | MAPK14 (0.57) | ALDH1A1KDM4EL3MBTL1MAPK14POLB | |
| SCHEMBL28783619 | 0.78 | ALDH1A1 (0.52) | ALDH1A1KDM4EL3MBTL1MAPK14POLB | |
| SCHEMBL4380091 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1MAPK14POLB | |
| SCHEMBL13635888 | 0.77 | L3MBTL1 (0.50) | ALDH1A1KDM4EL3MBTL1MAPK14POLB | |
| SCHEMBL4478413 | 0.76 | MAPK14 (0.56) | ALDH1A1KDM4EL3MBTL1MAPK14POLB | |
| SCHEMBL4383133 | 0.74 | MAPK14 (0.49) | ALDH1A1KDM4EL3MBTL1MAPK14POLB | |
| SCHEMBL4376114 | 0.74 | MAPK14 (0.64) | ALDH1A1KDM4EL3MBTL1MAPK14POLB | |
| SCHEMBL4476585 | 0.71 | MAPK14 (0.51) | ALDH1A1KDM4EL3MBTL1MAPK14POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |