Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | TTK | P33981 | 5/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2863237 | 0.93 | CSNK1D (0.52) | CSNK1DTTKMAP2K4MAPK1MAPK3 | |
| SCHEMBL2867437 | 0.86 | CSNK1D (0.47) | CSNK1DMAP2K4MAPK1MAPK3DGAT2 | |
| SCHEMBL2870355 | 0.86 | MAPK1 (0.50) | CSNK1DTTKMAP2K4MAPK1MAPK3 | |
| SCHEMBL2862635 | 0.86 | DGAT2 (0.56) | CSNK1DTTKDGAT2NTRK1ROCK2 | |
| SCHEMBL2863001 | 0.81 | NTRK1 (0.56) | CSNK1DTTKMAP2K4MAPK1MAPK3 | |
| SCHEMBL13198273 | 0.80 | DGAT2 (0.50) | CSNK1DTTKMAPK1DGAT2NTRK1 | |
| SCHEMBL2872610 | 0.78 | DGAT2 (0.56) | CSNK1DTTKMAPK1DGAT2NTRK1 | |
| SCHEMBL2866831 | 0.75 | CSNK1D (0.51) | CSNK1DDGAT2ROCK2 | |
| SCHEMBL2870798 | 0.75 | NTRK1 (0.52) | CSNK1DMAPK1DGAT2NTRK1ROCK2 | |
| SCHEMBL2857593 | 0.75 | MAP2K4 (0.48) | MAP2K4MAPK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |