Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.55 |
| ▸ | HTR7 | P34969 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386911 | 0.89 | TSHR (0.70) | GAAMAPTATMTSHRHTR1A | |
| Hydrochloric Acid SCHEMBL4380692 | 0.88 | TSHR (0.69) | GAAMAPTATMTSHRHTR1A | |
| SCHEMBL12124706 | 0.71 | HTR1A (1.00) | HTR1AHTR7 | |
| SCHEMBL13779939 | 0.71 | ALDH1A1 (0.79) | GAAMAPTATMTSHRNPC1 | |
| SCHEMBL4381097 | 0.70 | ALDH1A1 (0.69) | GAAMAPTATMTSHRNPC1 | |
| SCHEMBL12124544 | 0.69 | DRD2 (0.76) | HTR1AHTR7 | |
| SCHEMBL2008321 | 0.69 | MAPK1 (0.75) | MAPTTSHRALDH1A1MEN1KMT2A | |
| Benzene SCHEMBL7861838 | 0.69 | MAPK1 (0.75) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL23182640 | 0.68 | MAPK1 (0.73) | MAPTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL5717757 | 0.68 | MAPK1 (1.00) | MAPTTSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |