Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384247 | 0.89 | HRH3 (0.66) | HRH3POLBTDP1ALDH1A1GAA | |
| SCHEMBL7956272 | 0.79 | NPC1 (0.69) | HRH3ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL4377632 | 0.77 | MAPK1 (0.75) | POLBALDH1A1GAAMAPTKMT2A | |
| SCHEMBL4379155 | 0.74 | ENPP2 (0.67) | HRH3ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL14247599 | 0.72 | P2RX7 (0.52) | HRH3POLBALDH1A1MAPTKMT2A | |
| SCHEMBL7400055 | 0.72 | ITGB3 (0.54) | HRH3ALDH1A1GAAITGB3ITGA2B | |
| SCHEMBL1283182 | 0.72 | ME2 (0.56) | POLBALDH1A1MAPTKMT2AMAPK1 | |
| SCHEMBL7327928 | 0.71 | HRH3 (0.59) | HRH3POLBALDH1A1ITGB3ITGA2B | |
| SCHEMBL7402423 | 0.71 | USP2 (0.54) | POLBALDH1A1GAAMAPTITGB3 | |
| SCHEMBL4376118 | 0.71 | HRH3 (0.60) | HRH3POLBMAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |