Sugi Predict

Sugi Predict / Compounds / SCHEMBL1363640

SCHEMBL1363640

SCHEMBL1363640

NNC(=O)c1ccc(I)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MPO P05164 2/20 0.64
▸ CYP3A4 P08684 2/20 0.64
▸ KDM5A P29375 1/20 0.64
▸ BLM P54132 1/20 0.64
▸ GFER P55789 1/20 0.64
▸ PMP22 Q01453 1/20 0.64
▸ HIF1A Q16665 1/20 0.64
▸ MAPT P10636 4/20 0.61
▸ KDM4E B2RXH2 3/20 0.61
▸ ALDH1A1 P00352 3/20 0.61
▸ L3MBTL1 Q9Y468 2/20 0.61
▸ OGG1 O15527 1/20 0.61
▸ LMNA P02545 1/20 0.61
▸ CYP1A2 P05177 2/20 0.56
▸ CYP2D6 P10635 2/20 0.56
▸ ADORA3 P0DMS8 1/20 0.56
▸ CYP2A6 P11509 1/20 0.56
▸ CYP2C19 P33261 1/20 0.56
▸ CA1 P00915 4/20 0.55
▸ CA2 P00918 4/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL343630 0.87 MPO (0.80) MPOCYP3A4KDM5ABLMGFER
SCHEMBL2678949 0.87 MPO (0.80) MPOCYP3A4KDM5ABLMGFER
SCHEMBL28188923 0.85 MPO (0.76) MPOCYP3A4KDM5ABLMGFER
SCHEMBL11134828 0.80 MPO (0.70) MPOCYP3A4KDM5ABLMGFER
SCHEMBL752600 0.80 MPO (0.70) MPOCYP3A4KDM5ABLMGFER
SCHEMBL27556167 0.79 MPO (0.61) MPOCYP3A4KDM5ABLMGFER
SCHEMBL12687823 0.78 OGG1 (0.71) MPOCYP3A4KDM5ABLMGFER
SCHEMBL72425 0.78 MPO (0.67) MPOCYP3A4KDM5ABLMGFER
SCHEMBL21694316 0.78 HDAC6 (0.60) CA1CA2CA9TPMT
SCHEMBL328628 0.78 HIF1A (0.67) MPOCYP3A4KDM5ABLMGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116730942-B 1,3, 4-Oxadiazole-2 (3H) -thioketone compound and preparation method and application thereof 广东省科学院微生物研究所(广东省微生物分析检测中心) 2024-07-02 — — CN claimed
CN-116730942-A 1,3, 4-oxadiazole-2 (3H) -thioketone compound and preparation method and application thereof 广东省科学院微生物研究所(广东省微生物分析检测中心) 2023-09-12 — — CN claimed
CN-113416266-A Aromatic hydrazide compound-cyclodextrin inclusion compound and preparation method thereof 湖北工业大学 2021-09-21 — — CN claimed
CN-116157398-B Oxadiazole-based selective histone deacetylase 6 inhibitors 意大发马克股份公司 2025-03-11 — — CN disclosed
CN-116445150-B Aromatic amine compound containing oxadiazole and preparation method and application thereof 中国科学院福建物质结构研究所 2025-01-10 — — CN disclosed
CN-119039173-A Rupestonic acid hydrazide derivative and preparation method and application thereof 喀什大学 2024-11-29 — — CN disclosed
CN-118359601-A Aromatic acetylene derivative and preparation method and application thereof 浙江海正药业股份有限公司 2024-07-19 — — CN disclosed
CN-116730942-B 1,3, 4-Oxadiazole-2 (3H) -thioketone compound and preparation method and application thereof 广东省科学院微生物研究所(广东省微生物分析检测中心) 2024-07-02 — — CN disclosed
CN-116730942-B 1,3, 4-Oxadiazole-2 (3H) -thioketone compound and preparation method and application thereof 广东省科学院微生物研究所(广东省微生物分析检测中心) 2024-07-02 — — CN disclosed
US-20230286970-A1 NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS ITALFARMACO SPA (IT) 2023-09-14 — — US disclosed
CN-116730942-A 1,3, 4-oxadiazole-2 (3H) -thioketone compound and preparation method and application thereof 广东省科学院微生物研究所(广东省微生物分析检测中心) 2023-09-12 — — CN disclosed
US-20060089393-A1 Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors GLAXOSMITHKLINE LLC 2006-04-27 — — US disclosed
US-20060018908-A1 Compositions and methods for treating cancer ROSE, DAVID STUART 2006-01-26 — — US disclosed
US-20050058652-A1 Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer ROSE, DAVID STUART 2005-03-17 — — US disclosed
US-20050043388-A1 Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. 2005-02-24 — — US disclosed
EP-1499600-A1 HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2005-01-26 — — EP disclosed
EP-1439834-A1 OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) Applied Research Systems ARS Holding N.V. (AN) 2004-07-28 — — EP disclosed
WO-2003093248-A1 HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-11-13 — — WO disclosed
WO-2003037328-A1 OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) 2003-05-08 — — WO disclosed
US-5237099-A Insecticidal substituted and unsubstituted benzoic acid 1-alkyl, 2-alkyl and 2-cycloalkylhydrazides AMERICAN CYANAMID COMPANY (US) 1993-08-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060089393-A1 Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors MAPK1, MAPK7, MAP3K1 MPO 1009/4885CYP3A4 818/4885KDM5A 3963/4885
US-20050043388-A1 Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) PTPRO, PTPRE, PTPRZ1 MPO 2619/4885CYP3A4 1654/4885KDM5A 1835/4885
US-20230286970-A1 NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS HDAC6, HDAC1, HDAC3 MPO 1710/4885CYP3A4 3686/4885KDM5A 206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.