Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24663619 | 0.84 | ACHE (0.64) | MEN1KMT2AACHEALDH1A1MGLL | |
| SCHEMBL13152686 | 0.81 | ACHE (0.64) | MEN1KMT2AACHEHDAC3HDAC4 | |
| SCHEMBL7499151 | 0.81 | ACHE (0.59) | MEN1KMT2AACHEALDH1A1MGLL | |
| SCHEMBL3455469 | 0.80 | ACHE (0.68) | MEN1KMT2AACHELMNAMGLL | |
| SCHEMBL6973290 | 0.79 | EPHX1 (0.61) | MEN1KMT2AACHEALDH1A1LMNA | |
| SCHEMBL13472207 | 0.79 | ACHE (0.57) | MEN1KMT2AACHEALDH1A1MGLL | |
| SCHEMBL3614803 | 0.79 | ACHE (0.70) | MEN1KMT2AACHEALDH1A1MGLL | |
| SCHEMBL13152826 | 0.78 | ACHE (0.60) | MEN1KMT2AACHEHDAC3HDAC4 | |
| SCHEMBL17963568 | 0.78 | LMNA (0.42) | MEN1KMT2AALDH1A1LMNAHSD11B1 | |
| SCHEMBL1673861 | 0.78 | MAPT (0.73) | MEN1KMT2AACHEMGLLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304423-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2012-11-06 | — | — | US | disclosed |
| US-8304423-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2012-11-06 | — | — | US | disclosed |