Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MGLL | Q99685 | 2/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CPB1 | P15086 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24663619 | 0.84 | ACHE (0.64) | ACHEMEN1KMT2AMGLLHSD11B1 | |
| SCHEMBL6973290 | 0.83 | EPHX1 (0.61) | ACHEMEN1KMT2AMGLLHSD11B1 | |
| SCHEMBL1673861 | 0.82 | MAPT (0.73) | ACHEMEN1KMT2AMGLLHSD11B1 | |
| SCHEMBL13636742 | 0.81 | MEN1 (0.60) | ACHEMEN1KMT2AMGLLHSD11B1 | |
| SCHEMBL1720183 | 0.80 | MGLL (0.82) | ACHEMEN1KMT2AMGLLHSD11B1 | |
| SCHEMBL11616794 | 0.80 | ACHE (0.71) | ACHEMEN1KMT2AMGLLHSD11B1 | |
| SCHEMBL13472207 | 0.80 | ACHE (0.57) | ACHEMEN1KMT2AMGLLHSD11B1 | |
| SCHEMBL17430893 | 0.79 | ALDH1A1 (0.54) | ACHEMEN1KMT2APTPN1ALDH1A1 | |
| SCHEMBL3447241 | 0.79 | MGLL (0.66) | ACHEMEN1KMT2AMGLLHSD11B1 | |
| SCHEMBL3614803 | 0.79 | ACHE (0.70) | ACHEMEN1KMT2AMGLLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171122-A4 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1171122-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| WO-2000059502-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |
| US-4746669-A | Substituted thiazoles as immunoregulants | MERCK & CO., INC. (US) | 1988-05-24 | — | — | US | disclosed |