Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 6/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | PPARD | Q03181 | 4/20 | 0.35 |
| ▸ | PPARA | Q07869 | 4/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13441643 | 0.87 | FFAR1 (0.39) | LTB4RPTPN11PPARGPPARDPPARA | |
| SCHEMBL13442143 | 0.85 | PPARG (0.38) | LTB4RPTPN11PTPN1PTPN6PPARG | |
| SCHEMBL13637199 | 0.75 | LTB4R (0.42) | LTB4RPPARGPPARDPPARALTB4R2 | |
| SCHEMBL13637279 | 0.75 | PPARD (0.35) | PPARGPPARDPPARA | |
| SCHEMBL13637162 | 0.75 | LTB4R (0.40) | LTB4RTBXAS1PPARGPPARDPPARA | |
| SCHEMBL13637290 | 0.73 | ALDH1A1 (0.40) | — | |
| SCHEMBL13442144 | 0.66 | PPARG (0.52) | LTB4RPTPN11PTPN1PTPN6PPARG | |
| SCHEMBL5149062 | 0.64 | ABCC4 (0.67) | GSK3BRXRARXRBRXRG | |
| SCHEMBL13637285 | 0.63 | PLA2G4B (0.38) | LTB4RPPARGPPARDLTB4R2PLA2G4B | |
| SCHEMBL11684213 | 0.62 | PLA2G4B (0.69) | LTB4RPTPN11TBXAS1LTB4R2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |