Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.36 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29698855 | 0.83 | KDM4E (0.43) | KDM4EALDH1A1DRD2DRD3ACHE | |
| SCHEMBL630847 | 0.81 | KDM4E (0.62) | KDM4EALDH1A1DRD2DRD3ACHE | |
| SCHEMBL13638177 | 0.71 | KDM4E (0.39) | KDM4EALDH1A1DRD2DRD3ACHE | |
| SCHEMBL13638214 | 0.68 | SLC6A2 (0.39) | KDM4EALDH1A1DRD2DRD3ACHE | |
| SCHEMBL13847659 | 0.67 | KDM4E (0.58) | KDM4EALDH1A1DRD2DRD3ACHE | |
| SCHEMBL7590712 | 0.66 | SMN1; SMN2 (0.42) | KDM4EALDH1A1ACHEHTTMAOA | |
| SCHEMBL10651592 | 0.66 | KDM4E (0.60) | KDM4EDRD2DRD3SNCAHTT | |
| SCHEMBL13799409 | 0.64 | DRD2 (0.56) | DRD2DRD3ACHECYP19A1DRD1 | |
| SCHEMBL14279806 | 0.64 | DRD2 (0.56) | DRD2DRD3ACHECYP19A1DRD1 | |
| SCHEMBL16233623 | 0.64 | DRD2 (0.56) | DRD2DRD3ACHECYP19A1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286863-A1 | SULFAMATOBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286863-A1 | SULFAMATOBENZOTHIOPHENE DERIVATIVES | SULT1A1, SULT1E1, SULT2A1 | KDM4E 1985/4885ALDH1A1 79/4885DRD2 3483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.