Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPD | P32754 | 5/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177258 | 0.93 | HPD (0.34) | HPDGLAMAPK14KMT2AMEN1 | |
| SCHEMBL13638385 | 0.84 | GLA (0.36) | HPDGLAKMT2AMEN1P2RY12 | |
| SCHEMBL9922166 | 0.83 | P2RY12 (0.48) | HPDGLAMAPK14KMT2AMEN1 | |
| SCHEMBL13638585 | 0.82 | TERT (0.35) | HPDGLAKMT2AMEN1L3MBTL1 | |
| SCHEMBL14113598 | 0.79 | MAPK14 (0.31) | MAPK14 | |
| SCHEMBL13638648 | 0.78 | GLA (0.48) | HPDGLAKMT2AL3MBTL1MAPT | |
| SCHEMBL14228483 | 0.76 | GLA (0.35) | HPDGLAKMT2AMEN1P2RY12 | |
| SCHEMBL14228334 | 0.73 | TERT (0.39) | — | |
| SCHEMBL13638542 | 0.73 | PPARG (0.39) | P2RY12MAPTLMNATP53 | |
| SCHEMBL14228338 | 0.72 | TSHR (0.40) | L3MBTL1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |