Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638854 | 0.84 | RAB9A (0.62) | CYP11B2BRAFLRRK2ALDH1A1RAB9A | |
| SCHEMBL13162000 | 0.84 | CYP11B2 (0.76) | NAMPTCYP11B2BRAFLRRK2ALDH1A1 | |
| SCHEMBL13162552 | 0.82 | NAMPT (0.62) | NAMPTCYP11B2BRAFLRRK2ALDH1A1 | |
| SCHEMBL18160285 | 0.79 | CSF1R (0.74) | NAMPTCYP11B2LRRK2ALDH1A1HTT | |
| SCHEMBL27928412 | 0.79 | NAMPT (0.58) | NAMPTCYP11B2BRAFLRRK2ALDH1A1 | |
| SCHEMBL3943800 | 0.78 | BRAF (0.80) | NAMPTCYP11B2BRAFCSF1R | |
| SCHEMBL13163086 | 0.78 | SMN1; SMN2 (0.61) | NAMPTCYP11B2BRAFLRRK2ALDH1A1 | |
| SCHEMBL13638804 | 0.77 | RAB9A (0.62) | BRAFLRRK2ALDH1A1RAB9ANPC1 | |
| SCHEMBL13947029 | 0.75 | NAMPT (1.00) | NAMPTCYP11B2RAB9ANPC1CYP11B1 | |
| SCHEMBL31661935 | 0.74 | BRAF (0.79) | NAMPTBRAFALDH1A1NPC1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |