Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.62 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21056024 | 0.83 | PPARG (0.72) | CYP11B2CYP11B1BRAFSGMS2PPARG | |
| SCHEMBL21056019 | 0.83 | GRM5 (0.67) | CYP11B2CYP11B1BRAFSGMS2PPARG | |
| SCHEMBL13162545 | 0.83 | CYP11B2 (0.64) | CYP11B2CYP11B1BRAFSGMS2PPARG | |
| SCHEMBL13162335 | 0.83 | BRAF (0.76) | CYP11B2CYP11B1BRAFSGMS2PPARG | |
| SCHEMBL8611362 | 0.81 | CYP11B2 (0.67) | CYP11B2CYP11B1BRAFSGMS2PPARG | |
| SCHEMBL12079459 | 0.81 | CYP11B2 (0.68) | CYP11B2CYP11B1BRAFSGMS2PPARG | |
| SCHEMBL13163088 | 0.79 | CYP11B1 (0.59) | CYP11B2CYP11B1BRAFSGMS2PPARG | |
| SCHEMBL13638804 | 0.79 | RAB9A (0.62) | BRAFSGMS2LRRK2KDM4EMEN1 | |
| SCHEMBL31171360 | 0.77 | CYP11B2 (0.61) | CYP11B2CYP11B1BRAFSGMS2PPARG | |
| SCHEMBL15847396 | 0.76 | BRAF (0.77) | CYP11B2CYP11B1BRAFSGMS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |