Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.67 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21056019 | 0.90 | GRM5 (0.67) | CYP11B2CYP11B1MEN1KMT2ABRAF | |
| SCHEMBL31171360 | 0.86 | CYP11B2 (0.61) | CYP11B2CYP11B1MEN1KMT2ABRAF | |
| SCHEMBL12079459 | 0.85 | CYP11B2 (0.68) | CYP11B2CYP11B1MEN1KMT2AGAA | |
| SCHEMBL8178093 | 0.84 | GPR27 (0.76) | MEN1KMT2APKMGAAMAPT | |
| SCHEMBL13162545 | 0.82 | CYP11B2 (0.64) | CYP11B2CYP11B1MEN1KMT2ABRAF | |
| SCHEMBL21056024 | 0.82 | PPARG (0.72) | CYP11B2CYP11B1BRAFSGMS2PPARG | |
| SCHEMBL13162335 | 0.82 | BRAF (0.76) | CYP11B2CYP11B1MAPTBRAFLRRK2 | |
| SCHEMBL31171384 | 0.81 | CYP11B2 (0.57) | CYP11B2CYP11B1MEN1KMT2ABRAF | |
| SCHEMBL4878207 | 0.81 | CYP11B2 (0.72) | CYP11B2CYP11B1MEN1KMT2AGAA | |
| SCHEMBL8224938 | 0.81 | CYP11B2 (0.72) | CYP11B2CYP11B1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456435-B1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | UNIV LELAND STANFORD JUNIOR (US) | 2015-06-24 | — | — | EP | disclosed |
| US-20120225862-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | AUCKLAND UNIVSERVICES LIMITED (NZ) | 2012-09-06 | — | — | US | disclosed |
| EP-2456435-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | The Board of Trustees of The Leland Stanford Junior University (US) | 2012-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225862-A1 | HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE | BRDT, NISCH, PAICS | CYP11B2 862/4885CYP11B1 1543/4885MEN1 2511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.