Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6 | P05231 | 8/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13639320 | 0.90 | IL6 (0.63) | IL6FFAR1FFAR4GRIN1GRIN2B | |
| SCHEMBL13639301 | 0.85 | IL6 (0.60) | IL6FFAR1FFAR4GRIN1GRIN2B | |
| SCHEMBL13639328 | 0.83 | IL6 (0.55) | IL6FFAR1FFAR4GPBAR1MDM2 | |
| SCHEMBL4580821 | 0.83 | IL6 (0.76) | IL6PTGDR2GRM5FFAR1FFAR4 | |
| SCHEMBL13639316 | 0.83 | IL6 (0.57) | IL6PTGDR2GRM5GRIN1GRIN2B | |
| SCHEMBL4129581 | 0.83 | IL6 (0.76) | IL6PTGDR2GRM5FFAR1FFAR4 | |
| SCHEMBL4582029 | 0.83 | IL6 (0.56) | IL6KMT2A | |
| SCHEMBL4145214 | 0.82 | IL6 (0.46) | IL6GRM5GRIN1GRIN2BMAPT | |
| SCHEMBL13639334 | 0.82 | IL6 (0.54) | IL6ALDH1A1MAPTKMT2ATP53 | |
| SCHEMBL4142020 | 0.82 | IL6 (0.42) | IL6GRIN1GRIN2BMOGAT2MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |