Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6 | P05231 | 8/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.33 |
| ▸ | STK10 | O94804 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582029 | 0.86 | IL6 (0.56) | IL6ARCCNT1CDK9 | |
| SCHEMBL4579352 | 0.84 | IL6 (0.81) | IL6GRIN1GRIN2BARHTR2C | |
| SCHEMBL13639320 | 0.84 | IL6 (0.63) | IL6GRIN1GRIN2BHTR2C | |
| SCHEMBL13639295 | 0.83 | IL6 (0.53) | IL6GRIN1GRIN2BPTGDR2HTR2C | |
| SCHEMBL13639340 | 0.83 | IL6 (0.47) | IL6GRIN1GRIN2B | |
| SCHEMBL4581546 | 0.82 | IL6 (0.49) | IL6MDM2CCNT1CDK9 | |
| SCHEMBL4580569 | 0.81 | IL6 (0.48) | IL6GRM5SLKSTK10 | |
| SCHEMBL13639301 | 0.79 | IL6 (0.60) | IL6GRIN1GRIN2BMDM2CDK9 | |
| SCHEMBL4581371 | 0.79 | IL6 (0.47) | IL6GRM5SLKSTK10 | |
| SCHEMBL4145214 | 0.78 | IL6 (0.46) | IL6GRIN1GRIN2BGRM5SLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |