Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6 | P05231 | 8/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4581799 | 0.86 | IL6 (0.67) | IL6GPBAR1MCHR1KCNH2 | |
| SCHEMBL13639320 | 0.83 | IL6 (0.63) | IL6 | |
| SCHEMBL13639295 | 0.81 | IL6 (0.53) | IL6GPBAR1 | |
| SCHEMBL13639334 | 0.81 | IL6 (0.54) | IL6 | |
| SCHEMBL4580939 | 0.80 | IL6 (0.62) | IL6GPBAR1 | |
| SCHEMBL4579741 | 0.80 | IL6 (0.41) | IL6KCNH2 | |
| SCHEMBL13639301 | 0.80 | IL6 (0.60) | IL6 | |
| SCHEMBL4145214 | 0.80 | IL6 (0.46) | IL6 | |
| SCHEMBL13639310 | 0.80 | IL6 (0.51) | IL6 | |
| SCHEMBL4143767 | 0.80 | IL6 (0.65) | IL6GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |