Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TYMS | P04818 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.49 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13186877 | 0.93 | DHFR (0.52) | DHFRHDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL13640714 | 0.81 | DHFR (0.53) | DHFRHDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL479018 | 0.79 | DHFR (0.40) | DHFR | |
| SCHEMBL11913611 | 0.76 | DHFR (0.71) | DHFRHDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL3179385 | 0.75 | HDAC4 (0.60) | DHFRHDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL479220 | 0.75 | DHFR (0.54) | DHFRCA1CA2CA9 | |
| SCHEMBL13186954 | 0.75 | DHFR (0.59) | DHFRHDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL13985918 | 0.74 | DHFR (0.71) | DHFRHDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL221621 | 0.74 | DHFR (0.71) | DHFRHDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL3181815 | 0.73 | HDAC4 (0.54) | DHFRHDAC4HDAC7HDAC9HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120283219-A1 | DIAMINOPTERIDINE DERIVATIVES | BIORELIX, INC. | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283219-A1 | DIAMINOPTERIDINE DERIVATIVES | MPO, AOC1, DCTD | DHFR 19/4885HDAC4 2319/4885HDAC7 1983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.