Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 11/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | TLR4 | O00206 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | TYMS | P04818 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.67 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | GART | P22102 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29658170 | 1.00 | DHFR (0.71) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1230259 | 0.99 | DHFR (0.70) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3171572 | 0.98 | DHFR (0.69) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL30110296 | 0.92 | DHFR (0.62) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL11913611 | 0.91 | DHFR (0.71) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL13985918 | 0.91 | DHFR (0.71) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL13529957 | 0.91 | DHFR (0.60) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL10379252 | 0.90 | DHFR (0.59) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL14753789 | 0.89 | DHFR (0.66) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL22201137 | 0.88 | HDAC4 (0.70) | DHFRKDM4ETLR4MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7881871-B2 | Method for designing surfaces | BIO-LAYER PTY LIMITED (AU) | 2011-02-01 | — | — | US | claimed |
| EP-1700244-A4 | A METHOD FOR DESIGNING SURFACES | BIO LAYER PTY LTD (AU) | 2009-07-08 | — | — | EP | claimed |
| US-20070099235-A1 | Method for designing surfaces | BIO-LAYER PTY LIMITED (AU) | 2007-05-03 | — | — | US | claimed |
| EP-1700244-A1 | A METHOD FOR DESIGNING SURFACES | Bio-Layer Pty Limited (AU) | 2006-09-13 | — | — | EP | claimed |
| WO-2005057462-A1 | A METHOD FOR DESIGNING SURFACES | BIO-LAYER PTY LIMITED (AU) | 2005-06-23 | — | — | WO | claimed |
| US-20250114466-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2025-04-10 | — | — | US | disclosed |
| EP-2349274-B1 | FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES | ENDOCYTE INC (US) | 2025-04-09 | — | — | EP | disclosed |
| US-20250093340-A1 | ANTIBODIES TO METHOTREXATE AND USES THEREOF | ARES CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT | 2025-03-20 | — | — | US | disclosed |
| US-12163955-B2 | Antibodies to methotrexate and uses thereof | ARK DIAGNOSTICS, INC. (US) | 2024-12-10 | — | — | US | disclosed |
| EP-4457229-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | Byondis B.V. (NL) | 2024-11-06 | — | — | EP | disclosed |
| US-20240319176-A1 | ANTIBODIES TO METHOTREXATE AND USES THEREOF | ARES CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT | 2024-09-26 | — | — | US | disclosed |
| US-20230406859-A1 | METHOTREXATE ANALOGS AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2023-12-21 | — | — | US | disclosed |
| WO-2004031219-A1 | TUMOR TARGETING AGENTS AND USES THEREOF | KARYON OY (FI) | 2004-04-15 | — | — | WO | disclosed |
| WO-2004031220-A1 | TUMOR TARGETING AGENTS AND USES THEREOF | KARYON OY (FI) | 2004-04-15 | — | — | WO | disclosed |
| WO-2003106491-A2 | CELL PENETRATING PEPTIDES | CEPEP AB (SE) | 2003-12-24 | — | — | WO | disclosed |
| EP-1135390-A1 | METHOTREXATE DERIVATIVES | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2001-09-26 | — | — | EP | disclosed |
| US-6291673-B1 | Folic acid derivatives | PURDUE RESEARCH FOUNDATION | 2001-09-18 | — | — | US | disclosed |
| WO-2000034281-A1 | METHOTREXATE DERIVATIVES | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2000-06-15 | — | — | WO | disclosed |
| US-4079056-A | REACTING 2,4-DIAMINO-6-PTERIDINE-METHANOL-HBR WITH TRIPHENYLPHOSPHINE DIBROMIDE OR PHOSPHORUS TRIBROMIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1978-03-14 | — | — | US | disclosed |
| US-4077957-A | INTERMEDIATE FOR METHOTREXATE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1978-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240319176-A1 | ANTIBODIES TO METHOTREXATE AND USES THEREOF | MTX1, DHFR, MTX2 | DHFR 2/4885KDM4E 3678/4885TLR4 1984/4885 |
| US-20230406859-A1 | METHOTREXATE ANALOGS AND METHODS OF USE | MTX1, MTX2, MGMT | DHFR 9/4885KDM4E 3515/4885TLR4 2626/4885 |
| US-20250114466-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | DHFR, FOLR1, MTHFD2 | DHFR 1/4885KDM4E 2050/4885TLR4 2346/4885 |
| US-20250093340-A1 | ANTIBODIES TO METHOTREXATE AND USES THEREOF | MTX1, DHFR, MTX2 | DHFR 2/4885KDM4E 3678/4885TLR4 1984/4885 |
| US-12163955-B2 | Antibodies to methotrexate and uses thereof | MTX1, DHFR, MTX2 | DHFR 2/4885KDM4E 3678/4885TLR4 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.