Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28227610 | 0.88 | TDP1 (0.55) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL11295773 | 0.83 | ALDH1A1 (0.63) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL13637143 | 0.81 | ALDH1A1 (0.60) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL29453576 | 0.80 | ALDH1A1 (0.59) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL2211964 | 0.80 | ALDH1A1 (0.59) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL96841 | 0.80 | MEN1 (0.56) | ALDH1A1TDP1TSHRMAPK1MAPT | |
| SCHEMBL11408494 | 0.79 | RECQL (0.58) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL11212549 | 0.79 | ALDH1A1 (0.56) | ALDH1A1TDP1CYP3A4ALOX15TSHR | |
| SCHEMBL13643269 | 0.79 | TTR (0.44) | ALDH1A1TDP1ALOX15TSHRMAPK1 | |
| SCHEMBL11302992 | 0.79 | TSHR (0.58) | ALDH1A1TDP1CYP3A4TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772507-B2 | Imidazole-benzamide anti-cancer agents | CYTOKINETICS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130096315-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | QIAN XIANGPING (US) | 2013-04-18 | — | — | US | disclosed |
| US-20120283287-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | QIAN XIANGPING (US) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283287-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | KIF5B, KIF2C, PLK1 | ALDH1A1 2159/4885TDP1 217/4885CYP3A4 4782/4885 |
| US-20130096315-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | KIF5B, KIF2C, PLK1 | ALDH1A1 1977/4885TDP1 231/4885CYP3A4 4769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.