Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835094 | 0.89 | RAB9A (0.44) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL3836880 | 0.84 | RAB9A (0.43) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL5129395 | 0.83 | ALDH1A1 (0.43) | RAB9AKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5117566 | 0.80 | HTT (0.41) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL5130220 | 0.76 | KMT2A (0.44) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL5121680 | 0.75 | RAB9A (0.43) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL5117252 | 0.75 | SMN1; SMN2 (0.44) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL5122018 | 0.71 | DGAT2 (0.42) | RAB9AKMT2AMEN1ROCK2ROCK1 | |
| SCHEMBL27953140 | 0.70 | NPC1 (0.77) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3835063 | 0.69 | SLC40A1 (0.45) | SMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309566-B1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-10-07 | — | — | EP | disclosed |