Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Aniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | NT5E | P21589 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29159214 | 0.95 | TSHR (0.77) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 | |
| Aniline SCHEMBL11711110 | 0.93 | TSHR (0.82) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 | |
| Benzene SCHEMBL27671391 | 0.88 | TSHR (0.90) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 | |
| Hydrazine SCHEMBL5026988 | 0.87 | TSHR (0.89) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 | |
| Hydroxyamine SCHEMBL9651752 | 0.87 | TSHR (0.89) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 | |
| Hydrazine SCHEMBL11223582 | 0.87 | TSHR (0.89) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 | |
| SCHEMBL597672 | 0.87 | TSHR (1.00) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 | |
| SCHEMBL3409457 | 0.87 | TSHR (1.00) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 | |
| SCHEMBL2509 | 0.87 | TSHR (1.00) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 | |
| SCHEMBL30671620 | 0.87 | TSHR (1.00) | TSHRSMN1; SMN2ALDH1A1NT5EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4054541-B1 | SALT FORMS OF A COMPLEMENT COMPONENT C5A RECEPTOR | CHEMOCENTRYX INC (US) | 2026-05-06 | — | — | EP | disclosed |
| US-20240384065-A1 | SILOXANE RESIN COMPOSITION FOR FORMING CURED FILM, CURED FILM, AND METHOD OF PRODUCING POLYSILOXANE | TORAY INDUSTRIES, INC. (JP) | 2024-11-21 | — | — | US | disclosed |
| CN-117858927-A | Silicone resin composition for forming cured film, and method for producing polysiloxane | 东丽株式会社 | 2024-04-09 | — | — | CN | disclosed |
| CN-112513016-B | Sulfur-containing polymerizable monomer and use thereof | 尚美德齿科材料有限公司 | 2023-12-19 | — | — | CN | disclosed |
| WO-2023048062-A1 | SILOXANE RESIN COMPOSITION FOR FORMING CURED FILM, CURED FILM, AND METHOD FOR PRODUCING POLYSILOXANE | 東レ株式会社 | 2023-03-30 | — | — | WO | disclosed |
| CN-112940432-B | Polymerizable monomer for dental material, composition, adhesive dental material, and kit | 三井化学株式会社 | 2022-12-30 | — | — | CN | disclosed |
| EP-4054541-A1 | SALT FORMS OF A COMPLEMENT COMPONENT C5A RECEPTOR | ChemoCentryx, Inc. (US) | 2022-09-14 | — | — | EP | disclosed |
| CN-112513016-A | Sulfur-containing polymerizable monomer and use thereof | 尚美德齿科材料有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-107428934-A | Polyimide film, polyimide varnish, the product and laminate for having used polyimide film | 旭化成株式会社 | 2017-12-01 | — | — | CN | disclosed |
| US-8178271-B2 | Polymer having a sulfonic group or a sulfonate group and an amide group and method of producing same | CANON KABUSHIKI KAISHA (JP) | 2012-05-15 | — | — | US | disclosed |
| EP-1774410-B1 | CHARGE CONTROL AGENT, TONER, IMAGE FORMING METHOD, AND IMAGE FORMING APPARATUS | CANON KK (JP) | 2008-11-19 | — | — | EP | disclosed |
| CN-100393939-C | Method for producing a fiber composition | M REAL OYJ (FI) | 2008-06-11 | — | — | CN | disclosed |
| EP-1774410-A1 | CHARGE CONTROL AGENT, TONER, IMAGE FORMING METHOD, AND IMAGE FORMING APPARATUS | Canon Kabushiki Kaisha (JP) | 2007-04-18 | — | — | EP | disclosed |
| US-20070059627-A1 | Polymer having a sulfonic group or a sulfonate group and an amide group and method of producing same | CANON KABUSHIKI KAISHA (JP) | 2007-03-15 | — | — | US | disclosed |
| EP-1749035-A2 | POLYMER HAVING A SULFONIC GROUP OR A SULFONATE GROUP AND AN AMIDE GROUP AND METHOD OF PRODUCING SAME | Canon Kabushiki Kaisha (JP) | 2007-02-07 | — | — | EP | disclosed |
| CN-1798890-A | Method for producing a fiber composition | M REAL OYJ (FI) | 2006-07-05 | — | — | CN | disclosed |
| WO-2005121904-A1 | CHARGE CONTROL AGENT, TONER, IMAGE FORMING METHOD, AND IMAGE FORMING APPARATUS | CANON KABUSHIKI KAISHA (JP) | 2005-12-22 | — | — | WO | disclosed |
| WO-2005108441-A2 | POLYMER HAVING A SULFONIC GROUP OR A SULFONATE GROUP AND AN AMIDE GROUP AND METHOD OF PRODUCING SAME | CANON KABUSHIKI KAISHA (JP) | 2005-11-17 | — | — | WO | disclosed |
| US-4247699-A | REACTION OF AN ISATOIC ANHYDRIDE WITH MALONONITRILE FOLLOWED BY TREATMENT WITH A STRONG ACID OR BASE | PFIZER INC. (US) | 1981-01-27 | — | — | US | disclosed |
| US-4175193-A | INTERMEDIATES FOR 1-OXO-1H-6-ALKOXYPYRIMDO(1,2-A)QUINOLINE-2-CARBOXYLIC ACID AND ESTER ANTIALLERGENS | PFIZER INC. (US) | 1979-11-20 | — | — | US | disclosed |