Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13647019 | 0.89 | RAB9A (0.54) | NPC1RAB9AL3MBTL1KMT2ASMN1; SMN2 | |
| Bromide SCHEMBL11013141 | 0.87 | RAB9A (0.56) | NPC1RAB9AL3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL11210832 | 0.86 | CXCR3 (0.59) | NPC1RAB9AKMT2AMEN1MAPT | |
| Bromide SCHEMBL11207242 | 0.85 | CXCR3 (0.57) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL3867327 | 0.85 | SMN1; SMN2 (0.58) | NPC1RAB9AL3MBTL1KMT2ASMN1; SMN2 | |
| Bromide SCHEMBL3868794 | 0.80 | RAB9A (0.44) | NPC1RAB9AL3MBTL1KMT2ASMN1; SMN2 | |
| Bromide SCHEMBL3866348 | 0.79 | CYP1A1 (0.42) | NPC1RAB9AL3MBTL1KMT2ASMN1; SMN2 | |
| Bromide SCHEMBL11013450 | 0.77 | CXCR3 (0.60) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL962371 | 0.77 | ALDH1A1 (0.58) | RAB9AKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11007835 | 0.77 | GAA (0.46) | RAB9AL3MBTL1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601846-B2 | Compounds having activity as inhibitors of apoptosis | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-13 | — | — | US | disclosed |