Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CDYL2 | Q8N8U2 | 2/20 | 0.52 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13650902 | 0.85 | NPC1 (0.57) | SMN1; SMN2NPC1RAB9ATDP1TSHR | |
| SCHEMBL10546592 | 0.77 | L3MBTL1 (0.71) | SMN1; SMN2NPC1RAB9ATDP1TSHR | |
| SCHEMBL3866753 | 0.77 | KMT2A (0.45) | SMN1; SMN2NPC1RAB9ATDP1TSHR | |
| SCHEMBL3866750 | 0.77 | KMT2A (0.45) | SMN1; SMN2NPC1RAB9ATDP1TSHR | |
| SCHEMBL4616208 | 0.77 | L3MBTL1 (0.77) | SMN1; SMN2NPC1RAB9ATDP1TSHR | |
| SCHEMBL10662788 | 0.76 | L3MBTL1 (0.62) | SMN1; SMN2RAB9ATDP1TSHRALDH1A1 | |
| SCHEMBL11348784 | 0.76 | L3MBTL1 (0.60) | SMN1; SMN2TDP1TSHRALDH1A1MAPK1 | |
| SCHEMBL2332474 | 0.76 | L3MBTL1 (0.60) | SMN1; SMN2TDP1TSHRALDH1A1MAPK1 | |
| SCHEMBL4616232 | 0.76 | TDP1 (0.67) | SMN1; SMN2RAB9ATDP1TSHRALDH1A1 | |
| SCHEMBL11740900 | 0.75 | L3MBTL1 (0.65) | SMN1; SMN2TDP1TSHRALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601846-B2 | Compounds having activity as inhibitors of apoptosis | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-13 | — | — | US | disclosed |
| US-20060122178-A1 | Compounds having activity as inhibitors of apoptosis | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122178-A1 | Compounds having activity as inhibitors of apoptosis | BAD, CASP3, BAX | SMN1; SMN2 3506/4885NPC1 2532/4885RAB9A 3287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.