Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13761 | 0.88 | ALOX15 (0.40) | ALOX15KMT2ASMN1; SMN2ACHECYP1A2 | |
| SCHEMBL13824 | 0.85 | SCN4A (0.44) | ALOX15KMT2ASMN1; SMN2ACHEMAOB | |
| SCHEMBL14850080 | 0.84 | KMT2A (0.42) | ALOX15KMT2ASMN1; SMN2TSHRNR2E1 | |
| SCHEMBL17486523 | 0.84 | KMT2A (0.42) | ALOX15KMT2ASMN1; SMN2TSHRNR2E1 | |
| SCHEMBL19719294 | 0.84 | KMT2A (0.42) | ALOX15KMT2ASMN1; SMN2TSHRNR2E1 | |
| SCHEMBL773187 | 0.79 | ALOX15 (0.68) | ALOX15KMT2ASMN1; SMN2TSHRACHE | |
| SCHEMBL773194 | 0.78 | ALOX15 (0.67) | ALOX15KMT2ASMN1; SMN2TSHRACHE | |
| SCHEMBL772760 | 0.77 | SMN1; SMN2 (0.48) | KMT2ASMN1; SMN2TSHRNR2E1KDM4E | |
| SCHEMBL13672 | 0.77 | FFAR4 (0.46) | SMN1; SMN2TSHRCYP1A2MAOBAOC3 | |
| SCHEMBL13700996 | 0.76 | L3MBTL1 (0.44) | KDM4EFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216979-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-12-22 | — | — | US | disclosed |
| US-20130090326-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. (US) | 2013-04-11 | — | — | US | disclosed |
| WO-2011047323-A2 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090326-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | MPO, LPO, CAT | ALOX15 88/4885KMT2A 4518/4885SMN1; SMN2 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.