Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 10/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31621318 | 0.84 | AR (0.50) | ARTRPV4HTR2AHTR2CHTR2B | |
| SCHEMBL10733139 | 0.84 | AR (0.50) | ARTRPV4HTR2AHTR2CHTR2B | |
| SCHEMBL30424420 | 0.84 | CYP11B2 (0.42) | ARTRPV4CYP11B2CYP11B1HTR2A | |
| SCHEMBL2730532 | 0.84 | CYP11B2 (0.42) | ARTRPV4CYP11B2CYP11B1HTR2A | |
| SCHEMBL3333071 | 0.84 | CYP11B2 (0.42) | ARTRPV4CYP11B2CYP11B1HTR2A | |
| SCHEMBL7869818 | 0.82 | CYP11B2 (0.41) | ARTRPV4CYP11B2CYP11B1HTR2A | |
| SCHEMBL3338599 | 0.82 | AR (0.43) | ARTRPV4CYP11B2CYP11B1HTR2A | |
| SCHEMBL220882 | 0.80 | AR (0.53) | ARTRPV4CYP11B2CYP11B1HTR2A | |
| SCHEMBL4478973 | 0.80 | CYP11B2 (0.40) | ARTRPV4CYP11B2CYP11B1HTR2A | |
| SCHEMBL24495511 | 0.80 | AR (0.45) | ARTRPV4CYP11B2CYP11B1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774774-B1 | PYRIDINE SUBSTITUTED 2,2'-DI-9H-CARBAZOL-9-YL-[1,1'-BIPHENYL]-DICARBONITRILE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN OPTOELECTRONIC DEVICES | CYNORA GMBH (DE) | 2022-07-13 | — | — | EP | claimed |
| EP-3774774-A1 | PYRIDINE-SUBSTITUTED 2,2'-DI-9H-CARBAZOL-9-YL-[1,1'-BIPHENYL]DICARBONITRILE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN OPTOELECTRONIC APPARATUSES | cynora GmbH (DE) | 2021-02-17 | — | — | EP | claimed |
| WO-2019197407-A1 | PYRIDINE-SUBSTITUTED 2,2'-DI-9H-CARBAZOL-9-YL-[1,1'-BIPHENYL]DICARBONITRILE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN OPTOELECTRONIC APPARATUSES | CYNORA GMBH (DE) | 2019-10-17 | — | — | WO | claimed |
| EP-0731087-A1 | Process for the preparation of 2,4-dichloro-5-fluorobenzonitrile and 2,6-dichloro-3-fluorobenzonitrile | BAYER AG (DE) | 1996-09-11 | — | — | EP | claimed |
| JP-8245542-A | — | — | None | — | — | JP | disclosed |
| EP-3774774-B1 | PYRIDINE SUBSTITUTED 2,2'-DI-9H-CARBAZOL-9-YL-[1,1'-BIPHENYL]-DICARBONITRILE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN OPTOELECTRONIC DEVICES | CYNORA GMBH (DE) | 2022-07-13 | — | — | EP | disclosed |
| US-11325922-B2 | Process for the preparation of Crisaborole in a stable crystal form | OLON S.P.A. (IT) | 2022-05-10 | — | — | US | disclosed |
| EP-3728167-B1 | A PROCESS FOR THE PREPARATION OF CRISABOROLE | OLON SPA (IT) | 2021-12-01 | — | — | EP | disclosed |
| EP-3851429-A1 | A PROCESS FOR THE PURIFICATION OF CRISABOROLE | OLON S.p.A. (IT) | 2021-07-21 | — | — | EP | disclosed |
| US-20210070781-A1 | A PROCESS FOR THE PREPARATION OF CRISABOROLE | OLON S.P.A. (IT) | 2021-03-11 | — | — | US | disclosed |
| EP-3774774-A1 | PYRIDINE-SUBSTITUTED 2,2'-DI-9H-CARBAZOL-9-YL-[1,1'-BIPHENYL]DICARBONITRILE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN OPTOELECTRONIC APPARATUSES | cynora GmbH (DE) | 2021-02-17 | — | — | EP | disclosed |
| US-20200407377-A1 | PROCESS FOR THE PREPARATION OF CRISABOROLE IN A STABLE CRYSTAL FORM | OLON S.P.A. (IT) | 2020-12-31 | — | — | US | disclosed |
| US-20100041721-A1 | SELECTIVE ANDROGEN RECEPTOR MODULATORS | RADIUS HEALTH, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20090253758-A1 | Selective androgen receptor modulators | ELLIPSES PHARMA LTD (GB) | 2009-10-08 | — | — | US | disclosed |
| WO-2009105214-A2 | SELECTIVE ANDROGEN RECEPTOR MODULATORS | RADIUS HEALTH, INC. (US) | 2009-08-27 | — | — | WO | disclosed |
| EP-1911743-A1 | CYCLIC AMINE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-04-16 | — | — | EP | disclosed |
| EP-1911743-A1 | CYCLIC AMINE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-04-16 | — | — | EP | disclosed |
| US-5670694-A | AMMOXIDATION OF CORRESPONDING TOLUENE | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-23 | — | — | US | disclosed |
| JP-H08245542-A | PREPARATION OF 2,4-DICHLORO-5-FLUOROBENZONITRILE AND 2,5-DICHLORO-3-3FLUOROBENZONITRILE | BAYER AG | 1996-09-24 | — | — | JP | disclosed |
| EP-0731087-A1 | Process for the preparation of 2,4-dichloro-5-fluorobenzonitrile and 2,6-dichloro-3-fluorobenzonitrile | BAYER AG (DE) | 1996-09-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041721-A1 | SELECTIVE ANDROGEN RECEPTOR MODULATORS | AR, SHBG, IGF1R | AR 1/4885TRPV4 3628/4885CYP11B2 29/4885 |
| US-11325922-B2 | Process for the preparation of Crisaborole in a stable crystal form | FGB, SQLE, UGT2B17 | AR 3815/4885TRPV4 4499/4885CYP11B2 56/4885 |
| US-20200407377-A1 | PROCESS FOR THE PREPARATION OF CRISABOROLE IN A STABLE CRYSTAL FORM | FGB, SQLE, UGT2B17 | AR 3815/4885TRPV4 4499/4885CYP11B2 56/4885 |
| US-20210070781-A1 | A PROCESS FOR THE PREPARATION OF CRISABOROLE | SQLE, CYP11B1, UGT2B17 | AR 4521/4885TRPV4 4517/4885CYP11B2 9/4885 |
| US-20090253758-A1 | Selective androgen receptor modulators | AR, SHBG, GPR119 | AR 1/4885TRPV4 3034/4885CYP11B2 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.