Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17971206 | 0.86 | KDM4E (0.62) | SCN9AKDM4ELMNAP4HTMHDAC8 | |
| SCHEMBL13656131 | 0.80 | SCN9A (0.50) | SCN9AKDM4ELMNAP4HTMHDAC8 | |
| SCHEMBL13656027 | 0.80 | MEN1 (0.57) | ROCK2ROCK1KDM4ELMNAP4HTM | |
| SCHEMBL12052085 | 0.78 | ROCK2 (0.58) | ROCK2ROCK1HDAC8HDAC6HDAC1 | |
| SCHEMBL8247872 | 0.78 | ROCK2 (0.58) | ROCK2ROCK1HDAC8HDAC6HDAC1 | |
| SCHEMBL3374779 | 0.78 | SCN9A (0.54) | SCN9AKDM4EP4HTMSCN5AMAP4K4 | |
| SCHEMBL8255268 | 0.78 | ROCK2 (0.58) | ROCK2ROCK1HDAC8HDAC6HDAC1 | |
| SCHEMBL1647742 | 0.78 | LMNA (0.54) | SCN9AKDM4ELMNAP4HTMMAP4K4 | |
| SCHEMBL680063 | 0.78 | KDM4E (0.54) | SCN9AKDM4ELMNAP4HTMHDAC8 | |
| SCHEMBL279954 | 0.76 | HDAC1 (0.63) | SCN9ALMNAP4HTMHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247596-A1 | THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS | MERCK CANADA INC. (CA) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247596-A1 | THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS | PTGER4, PTGER1, PTGER2 | ROCK2 1321/4885ROCK1 1571/4885SCN9A 2463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.