Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13649482 | 0.81 | MEN1 (0.35) | ALDH1A1MEN1KMT2APOLBTDP1 | |
| SCHEMBL13656329 | 0.81 | ALDH1A1 (0.41) | PTGS2ALDH1A1LMNACYP1A2CYP2C19 | |
| SCHEMBL13656409 | 0.79 | ALDH1A1 (0.40) | PTGS2ALDH1A1LMNACYP1A2CYP2C19 | |
| SCHEMBL13656469 | 0.77 | PTGS2 (0.47) | PTGS2ALDH1A1LMNACYP1A2HSD17B10 | |
| SCHEMBL10044415 | 0.76 | PTGS2 (0.48) | PTGS2ALDH1A1LMNACYP1A2CYP2C19 | |
| SCHEMBL13656283 | 0.75 | TSHR (0.43) | PTGS2ALDH1A1LMNACYP1A2CYP2C19 | |
| SCHEMBL13656327 | 0.75 | ALDH1A1 (0.41) | PTGS2ALDH1A1LMNACYP1A2CYP2C19 | |
| SCHEMBL13656289 | 0.72 | MEN1 (0.41) | PTGS2ALDH1A1LMNACYP1A2CYP2C19 | |
| SCHEMBL7035765 | 0.70 | GABRA1 (0.51) | CYP1A2HSD17B10MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11232521 | 0.70 | MAPT (0.50) | PTGS2ALDH1A1CYP1A2HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253708-A1 | 2-ALKYNYL-6-PYRIDIN-2-YL-PYRIDAZINONES, 2-ALKYNYL-6-PYRIDIN-2-YL-DIHYDROPYRIDAZINONES, 2-ALKYNYL-6-PYRIMIDIN-2-YL-PYRIDAZINONES AND 2-ALKYNYL-6-PYRIMIDIN-2-YL-DIHYDROPYRIDAZINONES AND THEIR USE AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253708-A1 | 2-ALKYNYL-6-PYRIDIN-2-YL-PYRIDAZINONES, 2-ALKYNYL-6-PYRIDIN-2-YL-DIHYDROPYRIDAZINONES, 2-ALKYNYL-6-PYRIMIDIN-2-YL-PYRIDAZINONES AND 2-ALKYNYL-6-PYRIMIDIN-2-YL-DIHYDROPYRIDAZINONES AND THEIR USE AS FUNGICIDES | PDXK, DPM1, PNPO | PTGS2 2916/4885ALDH1A1 712/4885LMNA 2473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.