Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 8/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756376 | 0.88 | L3MBTL1 (0.35) | DAOKCNQ2CACNA1IKCNH2OPRM1 | |
| SCHEMBL15697002 | 0.80 | BRD4 (0.42) | DAOCACNA1IKCNH2OPRM1OPRL1 | |
| SCHEMBL18555520 | 0.78 | HRH3 (0.33) | HRH3DRD2DRD3 | |
| SCHEMBL19543665 | 0.78 | ALOX15 (0.38) | CACNA1IKCNH2SIGMAR1 | |
| SCHEMBL19543020 | 0.78 | ALOX15 (0.38) | CACNA1IKCNH2SIGMAR1 | |
| SCHEMBL20125805 | 0.78 | — | — | |
| SCHEMBL13246592 | 0.78 | ALOX15 (0.38) | CACNA1IKCNH2SIGMAR1 | |
| SCHEMBL12563635 | 0.78 | ALOX15 (0.38) | CACNA1IKCNH2SIGMAR1 | |
| SCHEMBL13038653 | 0.77 | NR3C1 (0.36) | KCNQ2 | |
| SCHEMBL12348842 | 0.76 | OPRM1 (0.37) | DAOCACNA1IKCNH2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605176-B2 | β-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-20 | — | — | US | disclosed |