Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 16/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 7/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13617189 | 0.73 | KDM4E (0.47) | KDM4ENPC1ALDH1A1MAPTHPGD | |
| SCHEMBL1851905 | 0.71 | KDM4E (0.60) | TBK1IKBKEKDM4ENPC1ALDH1A1 | |
| SCHEMBL1635678 | 0.63 | TBK1 (0.45) | TBK1IKBKENPC1ALDH1A1RAB9A | |
| SCHEMBL1636789 | 0.62 | TBK1 (0.44) | TBK1IKBKENPC1ALDH1A1RAB9A | |
| SCHEMBL1636266 | 0.60 | TBK1 (0.43) | TBK1IKBKEPIM1CSNK2A2CSNK2B | |
| SCHEMBL25813452 | 0.60 | KMT2A (0.49) | TBK1IKBKEGRM4KDM4ENPC1 | |
| SCHEMBL18174893 | 0.60 | KMT2A (0.49) | TBK1IKBKEKDM4ENPC1ALDH1A1 | |
| SCHEMBL1637279 | 0.60 | PLA2G2A (0.45) | TBK1IKBKEGRM4KDM4ENPC1 | |
| SCHEMBL24249945 | 0.59 | NPC1 (0.43) | TBK1IKBKEGRM4KDM4ENPC1 | |
| SCHEMBL14487016 | 0.58 | TBK1 (0.45) | TBK1IKBKENPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247559-A1 | Benzofuropyrimidinones | F12, BRI3BP, BRD1 | TBK1 2279/4885IKBKE 593/4885GRM4 2711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.