Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.72 |
| ▸ | GAA | P10253 | 10/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.72 |
| ▸ | HPGD | P15428 | 8/20 | 0.72 |
| ▸ | RECQL | P46063 | 3/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 9/20 | 0.67 |
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 5/20 | 0.63 |
| ▸ | GFER | P55789 | 4/20 | 0.63 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.63 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.59 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13973762 | 0.89 | GAA (0.73) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL3200875 | 0.88 | SMN1; SMN2 (0.67) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL31289457 | 0.88 | SMN1; SMN2 (0.67) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL13961658 | 0.87 | KDM4E (0.76) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL11284879 | 0.84 | GAA (0.73) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL22091290 | 0.84 | GAA (0.67) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL24049708 | 0.84 | MAPT (0.79) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL3194047 | 0.82 | ALDH1A1 (0.67) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL3834420 | 0.82 | ALDH1A1 (0.68) | MAPTGAAALDH1A1KDM4EHPGD | |
| SCHEMBL13221240 | 0.82 | GAA (0.77) | MAPTGAAALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331705-A1 | Fused Imidazole Derivatives as AHR Antagonists | SENDA BIOSCIENCES, INC. | 2023-10-19 | — | — | US | disclosed |
| US-20230331705-A1 | Fused Imidazole Derivatives as AHR Antagonists | SENDA BIOSCIENCES, INC. | 2023-10-19 | — | — | US | disclosed |
| WO-2021236717-A1 | FUSED IMIDAZOLE DERIVATIVES AS AHR ANTAGONISTS | SENDA BIOSCIENCES, INC. (US) | 2021-11-25 | — | — | WO | disclosed |
| US-20100120802-A1 | Novel Anti-Inflammatory and Analgesic Heterocyclic Amidines that Inhibit Nitrogen Oxide (NO) Production | MAKOVEC FRANCESCO | 2010-05-13 | — | — | US | disclosed |
| US-7674809-B2 | Anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production | ROTTAPHARM S.P.A. (IT) | 2010-03-09 | — | — | US | disclosed |
| US-20050197331-A1 | Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production | ROTTAPHARM SPA | 2005-09-08 | — | — | US | disclosed |
| EP-1571142-A1 | Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production | Rottapharm S.p.A. (IT) | 2005-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120802-A1 | Novel Anti-Inflammatory and Analgesic Heterocyclic Amidines that Inhibit Nitrogen Oxide (NO) Production | NOS3, NOS1, NOS2 | MAPT 4542/4885GAA 4310/4885ALDH1A1 1195/4885 |
| US-20050197331-A1 | Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production | NOS3, NOS1, NOS2 | MAPT 4542/4885GAA 4310/4885ALDH1A1 1195/4885 |
| US-20230331705-A1 | Fused Imidazole Derivatives as AHR Antagonists | AHR, ARNT, AIPL1 | MAPT 4023/4885GAA 3368/4885ALDH1A1 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.