SCHEMBL136586

SCHEMBL136586

CC1=Cc2c(-c3ccc(C(F)(F)F)cc3)cccc2C1[Zr](Cl)(Cl)(C1C(C)=Cc2c(-c3ccc(C(F)(F)F)cc3)cccc21)[SiH](C)C

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ENPP1 P22413 1/20 0.31
BACE1 P56817 1/20 0.31
DRD2 P14416 1/20 0.31
JAK2 O60674 1/20 0.30
KIF11 P52732 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5952865 0.91
SCHEMBL5837577 0.89 HTR1A (0.34)
SCHEMBL5951591 0.89 ENPP1 (0.32) ENPP1BACE1DRD2JAK2KIF11
SCHEMBL273374 0.89 BRD4 (0.31)
SCHEMBL5836947 0.88 RORC (0.36)
SCHEMBL6065061 0.87 BACE1 (0.32) BACE1DRD2JAK2KIF11
SCHEMBL5952016 0.86 HTR2C (0.32)
SCHEMBL141357 0.86
SCHEMBL5952255 0.86 DRD2 (0.34) ENPP1BACE1DRD2
SCHEMBL2512916 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060166813-A1 Preparation of supported catalyst systems BASELL POLYOLEFINE GMBH (DE) 2006-07-27 US claimed
EP-2576642-B1 PROCESS FOR PREPARING A SUPPORTED CATALYST SYSTEM FOR OLEFIN POLYMERIZATION, THE CATALYST SYSTEM AND ITS USE BASELL POLYOLEFINE GMBH (DE) 2017-08-16 EP disclosed
EP-2513166-B1 PROCESS FOR THE PREPARATION OF SUPPORTED CATALYSTS BASELL POLYOLEFINE GMBH (DE) 2017-04-05 EP disclosed
EP-1824888-B1 MONOCYCLOPENTADIENYL COMPLEXES BASELL POLYOLEFINE GMBH (DE) 2017-01-18 EP disclosed
US-8999875-B2 Process for preparing a supported catalyst system for olefin polymerization, the catalyst system and its use BASELL POLYOLEFINE GMBH (DE) 2015-04-07 US disclosed
EP-2415792-B1 COPOLYMER OF OLEFIN AND CONJUGATED DIENE, AND PROCESS FOR PRODUCING SAME MITSUI CHEMICALS INC (JP) 2014-11-12 EP disclosed
EP-1740626-B1 CATALYST SYSTEM FOR OLEFIN POLYMERIZATION, ITS PRODUCTION AND USE BASELL POLYOLEFINE GMBH (DE) 2014-10-22 EP disclosed
US-8859451-B2 Process for the preparation of supported catalysts BASELL POLYOLEFINE GMBH (DE) 2014-10-14 US disclosed
US-8680001-B2 Preparation of supported catalyst systems containing reduced amounts of aluminoxanes BASELL POLYOLEFINE GMBH (DE) 2014-03-25 US disclosed
US-8664140-B2 Catalyst system for olefin polymerization, its production and use BASELL POLYOLEFINE GMBH (DE) 2014-03-04 US disclosed
WO-2004018489-A1 MONOCYCLOPENTADIENYL COMPLEXES BASELL POLYOLEFINE GMBH (DE) 2004-03-04 WO disclosed
US-20040033890-A1 Catalyst system for carrying out olefin polymerization comprising a calcined hydro-talcite serving as a supporting material LYONDELL CHEMICAL TECHNOLOGY, L.P. 2004-02-19 US disclosed
WO-2004007569-A1 PREPARATION OF CATALYST SYSTEMS BASELL POLYOLEFINE GMBH (DE) 2004-01-22 WO disclosed
US-20030176275-A1 Catalytic solid supported on calcined hydrotalcite for olefinic polymerisation BASELL POLYOLEFINE GMBH (DE) 2003-09-18 US disclosed
US-20030078340-A1 Impregnating a mechanically fluidized porous particulate support material with a catalyst and polymerizing monomer(s) to produce polymer; heating mixture antioxidants, ultraviolet radiation stabilizer, diluent and metal stearate; depositing BOREALIS TECHNOLOGY OY (FI) 2003-04-24 US disclosed
US-20030009046-A1 Preparation of preparing substituted indanones EQUISTAR CHEMICALS, LP 2003-01-09 US disclosed
EP-0653433-B1 Novel transition metal compound, olefin polymerization catalyst component comprising the transition metal compound, olefin polymerization catalyst comprising the olefin polymerization catalyst component, and process for olefin polymerization MITSUI CHEMICALS INC (JP) 1999-01-13 EP disclosed
US-5859272-A METALLOCENES; PRODUCES POLYOLEFINS HAVING A HIGH MELTING POINT AND A HIGH MOLECULAR WEIGHT; HIGH POLYMERIZATION ACTIVITY MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1999-01-12 US disclosed
US-5616663-A TRANSITION METAL COMPOUND, ALUMINOXANE, COMPOUND WHICH REACTS WITH TRANSITION METAL COMPOUND TO FORM ION PAIR MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1997-04-01 US disclosed
EP-0653433-A1 Novel transition metal compound, olefin polymerization catalyst component comprising the transition metal compound, olefin polymerization catalyst comprising the olefin polymerization catalyst component, and process for olefin polymerization MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-05-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030009046-A1 Preparation of preparing substituted indanones CYP1A2, CYP1B1, CYP1A1 ENPP1 4183/4885BACE1 1435/4885DRD2 1860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.