Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | USP14 | P54578 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.30 |
| ▸ | TYK2 | P29597 | 2/20 | 0.30 |
| ▸ | JAK3 | P52333 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | LCAT | P04180 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755761 | 0.81 | SLC6A3 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL13985419 | 0.78 | PDE4B (0.34) | PDE4BPDE4DUSP14DPP4PIK3CA | |
| SCHEMBL13660313 | 0.77 | PDE4B (0.44) | PDE4BPDE4DUSP14JAK2PIK3CA | |
| SCHEMBL13985513 | 0.75 | LCAT (0.35) | PDE4BPDE4DUSP14DPP4PIK3CA | |
| SCHEMBL4755218 | 0.75 | LCAT (0.35) | PDE4BPDE4DUSP14DPP4PIK3CA | |
| SCHEMBL4753738 | 0.68 | JAK2 (0.35) | JAK2PIK3CASYKJAK1TYK2 | |
| SCHEMBL4753319 | 0.63 | MEN1 (0.40) | — | |
| SCHEMBL13985524 | 0.63 | MEN1 (0.40) | — | |
| SCHEMBL4755767 | 0.62 | CHRNB2 (0.34) | USP14PIK3CA | |
| SCHEMBL4789984 | 0.62 | KCNH2 (0.32) | KCNH2GPR119LCAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |