Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | USP14 | P54578 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13985504 | 1.00 | CHRNB2 (0.36) | CHRNB2CHRNA4CYP11B2CHRNB4CHRNA3 | |
| SCHEMBL13985522 | 0.87 | CRHR1 (0.41) | POLBCRHR1 | |
| SCHEMBL4756481 | 0.87 | CRHR1 (0.41) | POLBCRHR1 | |
| SCHEMBL13985419 | 0.85 | PDE4B (0.34) | PIK3CAUSP14 | |
| SCHEMBL4755765 | 0.81 | CHRNB2 (0.34) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3CA | |
| SCHEMBL4755767 | 0.81 | CHRNB2 (0.34) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3CA | |
| SCHEMBL13660414 | 0.76 | SMN1; SMN2 (0.34) | CHRNB2CHRNA4CYP11B2POLB | |
| SCHEMBL13660308 | 0.75 | CHRNB2 (0.31) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13660461 | 0.75 | HRH3 (0.37) | CHRNB2CHRNA4CYP11B2CHRNB4CHRNA3 | |
| SCHEMBL13985523 | 0.73 | PIK3CA (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |