Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13660462 | 0.90 | POLB (0.34) | — | |
| SCHEMBL13660414 | 0.80 | SMN1; SMN2 (0.34) | CHRNB2CHRNA4 | |
| SCHEMBL13660461 | 0.80 | HRH3 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13985504 | 0.75 | CHRNB2 (0.36) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4756478 | 0.75 | CHRNB2 (0.36) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13660458 | 0.75 | DRD1 (0.35) | — | |
| SCHEMBL13660314 | 0.73 | PDE4B (0.34) | — | |
| SCHEMBL3169620 | 0.70 | DRD1 (0.37) | — | |
| SCHEMBL3169614 | 0.70 | DRD1 (0.37) | — | |
| SCHEMBL13660412 | 0.69 | HRH3 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |