Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | AOC2 | O75106 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL534786 | 0.78 | TSHR (0.45) | TSHRSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL96749 | 0.76 | TSHR (0.44) | TSHRSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL194092 | 0.76 | TSHR (0.43) | TSHRSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL3021083 | 0.76 | CA1 (0.62) | TSHRSMN1; SMN2KMT2AALDH1A1CYP1A2 | |
| SCHEMBL12301112 | 0.74 | TSHR (0.42) | TSHRSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL22207361 | 0.74 | TSHR (0.42) | TSHRSMN1; SMN2MEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL28454112 | 0.74 | CA1 (0.59) | TSHRSMN1; SMN2ALDH1A1CYP1A2KDM4E | |
| SCHEMBL12853863 | 0.73 | KMT2A (0.41) | TSHRSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL5535600 | 0.73 | SCN4A (0.42) | TSHRSMN1; SMN2MEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL28937033 | 0.73 | CA1 (0.56) | TSHRSMN1; SMN2KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160207905-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | BLUEPRINT MEDICINES CORPORATION | 2016-07-21 | — | — | US | disclosed |
| US-20150067940-A1 | PBO Fibers with Improved Mechanical Properties when Exposed to High Temperatures and High Relative Humidity | BATTELLE MEMORIAL INSTITUTE (US) | 2015-03-12 | — | — | US | disclosed |
| US-20140231756-A1 | PHOSPHORESCENT COMPOUND WITH FUSED RNG SUBSTITUTION | UNIVERSAL DISPLAY CORPORATION (US) | 2014-08-21 | — | — | US | disclosed |
| US-8637516-B2 | Compounds and compositions as TRK inhibitors | IRM LLC (BM) | 2014-01-28 | — | — | US | disclosed |
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | disclosed |
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1790649-A1 | Substituted bicyclic pyrimidone derivatives | Sanofi-Aventis (FR) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207905-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | TYMP, EGFR, TK1 | TSHR 2314/4885SMN1; SMN2 3022/4885MEN1 4787/4885 |
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | TSHR 61/4885SMN1; SMN2 3100/4885MEN1 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.