Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1013058 | 0.86 | HSD11B1 (0.51) | HSD11B1CYP1A2HTTNPC1SMN1; SMN2 | |
| SCHEMBL1015257 | 0.82 | HSD11B1 (0.51) | HSD11B1CYP1A2HSD17B10NPC1SMN1; SMN2 | |
| SCHEMBL13667410 | 0.77 | HSD11B1 (0.49) | HSD11B1CYP1A2HSD17B10HTTSYK | |
| SCHEMBL12272538 | 0.71 | NNMT (0.46) | HTTSMN1; SMN2SYKNNMTPARP1 | |
| SCHEMBL740927 | 0.71 | HSD11B1 (0.57) | HSD11B1CYP1A2HSD17B10NPC1SMN1; SMN2 | |
| SCHEMBL1015456 | 0.71 | RAB9A (0.45) | HSD11B1CYP1A2HSD17B10HTTNPC1 | |
| SCHEMBL584137 | 0.70 | NNMT (0.43) | SYKNNMTALDH1A1PARP1 | |
| SCHEMBL30945485 | 0.69 | HSD11B1 (0.45) | HSD11B1HTTNPC1SMN1; SMN2NFKB1 | |
| SCHEMBL12575429 | 0.68 | NNMT (0.45) | SYKNNMTALDH1A1NPSR1RXFP1 | |
| SCHEMBL27893255 | 0.68 | CYP1A2 (0.48) | HSD11B1CYP1A2HSD17B10HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130496-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | WO | disclosed |