Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 15/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 15/20 | 0.62 |
| ▸ | HTR2B | P41595 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | NQO2 | P16083 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18183442 | 0.84 | MTNR1B (0.84) | MTNR1AMTNR1BHTR2BHTR2C | |
| SCHEMBL1094979 | 0.83 | MTNR1A (0.63) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL11304565 | 0.82 | MTNR1A (0.66) | MTNR1AMTNR1BHTR2BHTR2CSMN1; SMN2 | |
| SCHEMBL7313971 | 0.80 | LMNA (0.56) | MTNR1AMTNR1BSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL8230324 | 0.80 | HTR2A (0.54) | MTNR1AMTNR1BHTR2C | |
| SCHEMBL8070269 | 0.79 | MTNR1A (0.71) | MTNR1AMTNR1BHTR2BHTR2C | |
| SCHEMBL7314187 | 0.77 | POLB (0.65) | CYP1A2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7320887 | 0.77 | MEN1 (0.65) | MTNR1AMTNR1BMEN1RAB9AKMT2A | |
| SCHEMBL7308036 | 0.76 | HSD17B10 (0.50) | MTNR1AMTNR1BSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL8608340 | 0.76 | MTNR1A (0.71) | MTNR1AMTNR1BHTR2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111859-A1 | 5HT2C receptor modulator compositions and methods of use | Arena Pharmaceuticals, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |