Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.42 |
| ▸ | HTR2C | P28335 | 10/20 | 0.42 |
| ▸ | HTR2B | P41595 | 10/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1105041 | 0.83 | HTR2C (0.60) | HTR2AHTR2CHTR2B | |
| SCHEMBL30468465 | 0.74 | ADRA2A (0.49) | HTR2AHTR2CHTR2B | |
| SCHEMBL2496866 | 0.70 | HTR2C (0.44) | HTR2AHTR2CHTR2B | |
| SCHEMBL9288286 | 0.69 | HTR2A (0.36) | HTR2AHTR2CHTR2BPNMT | |
| SCHEMBL13673172 | 0.68 | HTR2C (0.69) | HTR2AHTR2CHTR2B | |
| SCHEMBL8301875 | 0.67 | KDM4E (0.51) | HTR2AHTR2CHTR2B | |
| SCHEMBL3162737 | 0.66 | HTR2A (0.74) | HTR2AHTR2CHTR2BMAOATSHR | |
| SCHEMBL22609757 | 0.66 | HTR2C (0.60) | HTR2AHTR2CHTR2BMAOA | |
| SCHEMBL29788066 | 0.66 | HTR2A (0.61) | HTR2AHTR2CHTR2BPNMTMAOA | |
| SCHEMBL329913 | 0.66 | HTR2A (0.61) | HTR2AHTR2CHTR2BPNMTMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111859-A1 | 5HT2C receptor modulator compositions and methods of use | Arena Pharmaceuticals, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |