Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 11/20 | 0.57 |
| ▸ | PPARD | Q03181 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | APAF1 | O14727 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 2/20 | 0.51 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.51 |
| ▸ | CDC25A | P30304 | 1/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.50 |
| ▸ | S100A4 | P26447 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13649357 | 0.89 | MAPT (0.59) | FFAR1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL7905154 | 0.86 | S100A4 (0.57) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL16938304 | 0.84 | STAT3 (0.46) | FFAR1PPARDPPARAMAPTKDM4E | |
| SCHEMBL30005823 | 0.83 | MAPT (0.56) | FFAR1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL4446630 | 0.83 | MAPT (0.56) | FFAR1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL11421782 | 0.82 | MAPT (0.55) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL12761936 | 0.81 | TBXAS1 (0.47) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL9709635 | 0.81 | MAPT (0.54) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL21940525 | 0.81 | MAPT (0.54) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL29263294 | 0.81 | MAPT (0.54) | MAPTKDM4EALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257515-B1 | 1,4-NAPHTHOQUINONE DERIVATIVES AND THERAPEUTIC USE THEREOF | CENTRE NAT RECH SCIENT (FR) | 2017-05-17 | — | — | EP | disclosed |
| US-9090549-B2 | 1,4-naphthoquinones derivatives and therapeutic use thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2015-07-28 | — | — | US | disclosed |
| WO-2009118327-A1 | 1,4-NAPHTHOQUINONE DERIVATIVES AND THERAPEUTIC USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-10-01 | — | — | WO | disclosed |