Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDLR | P01130 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 4/20 | 0.54 |
| ▸ | MMP9 | P14780 | 3/20 | 0.54 |
| ▸ | MMP8 | P22894 | 3/20 | 0.54 |
| ▸ | MMP13 | P45452 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14642393 | 0.87 | TP53 (0.72) | MAPTLMNAGAATP53RXFP1 | |
| SCHEMBL13679606 | 0.85 | MAPT (0.66) | LDLRMAPTLMNAGAATP53 | |
| SCHEMBL14615285 | 0.82 | MAPT (0.73) | MAPTLMNAGAATP53RXFP1 | |
| SCHEMBL2244921 | 0.82 | MMP2 (0.78) | MAPTLMNATP53ALDH1A1MAPK1 | |
| SCHEMBL14615287 | 0.78 | TP53 (0.62) | MAPTLMNAGAATP53RXFP1 | |
| SCHEMBL13679578 | 0.78 | MAPT (0.73) | MAPTLMNAGAATP53RXFP1 | |
| SCHEMBL8768635 | 0.77 | MMP2 (0.65) | MAPTTP53ALDH1A1MMP2MMP9 | |
| SCHEMBL14615294 | 0.77 | MAPT (0.61) | MAPTLMNAGAATP53RXFP1 | |
| SCHEMBL27202499 | 0.76 | MMP2 (0.68) | MAPTALDH1A1HSD17B10MMP2MMP9 | |
| SCHEMBL4162041 | 0.76 | KDR (0.56) | LMNAGAATP53RXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |