Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | LDLR | P01130 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679711 | 0.88 | TP53 (0.74) | MAPTLMNAGAATP53RXFP1 | |
| SCHEMBL13679620 | 0.85 | LDLR (0.65) | MAPTLMNAGAALDLRTP53 | |
| SCHEMBL9041899 | 0.81 | KDM4E (0.62) | MAPTLMNAGAATP53KDM4E | |
| SCHEMBL13679715 | 0.80 | MAPT (0.69) | MAPTLMNATP53MEN1KMT2A | |
| SCHEMBL27310368 | 0.80 | ITK (0.51) | MAPTLMNAGAALDLRTP53 | |
| SCHEMBL14615275 | 0.79 | MAPT (0.80) | MAPTLMNAGAATP53RXFP1 | |
| SCHEMBL14615299 | 0.76 | MAPT (0.66) | MAPTTP53KDM4EMEN1KMT2A | |
| SCHEMBL13456646 | 0.76 | MAPT (0.58) | MAPTLMNAGAALDLRTP53 | |
| SCHEMBL13679559 | 0.76 | MEN1 (0.78) | MAPTLDLRTP53MEN1KMT2A | |
| SCHEMBL13679573 | 0.75 | ADORA2A (0.57) | MAPTLDLRKDM4EMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |