Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ACACA | Q13085 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
| ▸ | FPR2 | P25090 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17144996 | 0.89 | KDM4E (0.65) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL16385162 | 0.88 | RAB9A (0.59) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL16385165 | 0.85 | ALDH1A1 (0.47) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL15256614 | 0.85 | ALDH1A1 (0.55) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL16385231 | 0.85 | KMO (0.52) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL16385293 | 0.85 | MAPT (0.58) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL14819917 | 0.83 | BRD4 (0.51) | KDM4ENPC1ALDH1A1HSD17B10HPGD | |
| SCHEMBL16385227 | 0.82 | CTSS (0.51) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL7053613 | 0.82 | HDAC8 (0.47) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL17144647 | 0.81 | KDM4E (0.56) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |