Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.56 |
| ▸ | GSK3B | P49841 | 3/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | PRF1 | P14222 | 6/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680969 | 0.76 | GSK3B (0.43) | CLK4GSK3BNTRK1FLT3DAPK3 | |
| SCHEMBL13680699 | 0.76 | HSD17B1 (0.51) | GSK3BGRM5 | |
| SCHEMBL13680592 | 0.75 | PRF1 (0.55) | PRF1 | |
| SCHEMBL13680532 | 0.73 | CLK4 (0.78) | CLK4GSK3BNTRK1FLT3DAPK3 | |
| SCHEMBL148819 | 0.72 | PARP10 (0.68) | CLK4GSK3BNTRK1FLT3DAPK3 | |
| SCHEMBL8167297 | 0.71 | CLK4 (0.75) | CLK4GSK3BNTRK1FLT3DAPK3 | |
| Ethane SCHEMBL27832823 | 0.71 | PARP10 (0.66) | CLK4GSK3BNTRK1FLT3DAPK3 | |
| SCHEMBL13680600 | 0.71 | GRIA1 (0.57) | TGFBR1ACVR1 | |
| SCHEMBL20923873 | 0.71 | PRF1 (0.62) | CLK4GSK3BNTRK1FLT3DAPK3 | |
| SCHEMBL15984853 | 0.71 | GSK3B (0.56) | CLK4GSK3BNTRK1FLT3DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |