Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19064527 | 0.74 | HPGDS (0.50) | TRPV4PIK3CAKCNH2PI4KBMAP4K4 | |
| SCHEMBL14937962 | 0.74 | CYP1A2 (0.44) | TRPV4PIK3CAKCNH2PI4KBMAP4K4 | |
| SCHEMBL13680603 | 0.74 | PTGS2 (0.50) | PTGS2 | |
| SCHEMBL26849009 | 0.72 | SLC34A1 (0.43) | TRPV4PIK3CAKCNH2PI4KBMAP4K4 | |
| SCHEMBL1719257 | 0.71 | PTGS2 (0.44) | TRPV4PTGS2PIK3CAKCNH2PI4KB | |
| SCHEMBL15121154 | 0.68 | TRPV4 (0.46) | TRPV4PIK3CAKCNH2PI4KBMAP4K4 | |
| SCHEMBL27945325 | 0.68 | USP2 (0.36) | — | |
| SCHEMBL16906665 | 0.68 | PTGS2 (0.45) | TRPV4PTGS2PIK3CAKCNH2PI4KB | |
| SCHEMBL17247907 | 0.68 | CYP2A6 (0.53) | TRPV4PTGS2PIK3CAKCNH2PI4KB | |
| SCHEMBL9157341 | 0.68 | PIK3CA (0.46) | TRPV4PTGS2PIK3CAKCNH2PI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |