Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 6/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29588174 | 0.79 | KIF11 (0.48) | PTGS2TP53GAAMAPTPOLB | |
| SCHEMBL13680602 | 0.74 | TRPV4 (0.42) | PTGS2 | |
| SCHEMBL5207654 | 0.74 | SRD5A2 (0.59) | BACE1 | |
| SCHEMBL6287395 | 0.72 | PTGS2 (0.67) | PTGS2MAPTKIF11 | |
| SCHEMBL5204511 | 0.71 | MAPT (0.53) | PTGS2TP53MAPTPOLBBACE1 | |
| SCHEMBL14360705 | 0.71 | MAPT (0.50) | GAAMAPTPOLBBACE1 | |
| SCHEMBL8989237 | 0.70 | KIF11 (0.47) | TP53GAAMAPTPOLBKIF11 | |
| SCHEMBL6279228 | 0.70 | PTGS2 (0.64) | PTGS2TP53MAPTPOLBRAB9A | |
| SCHEMBL5209142 | 0.69 | KIF11 (0.47) | PTGS2TP53GAAMAPTPOLB | |
| SCHEMBL27560774 | 0.69 | PGR (0.33) | PTGS2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |