Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.57 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31381049 | 0.82 | DYRK1A (0.71) | DYRK1ATGFBR1TGFBR2RETPIK3CA | |
| SCHEMBL13680666 | 0.81 | TGFBR1 (0.68) | DYRK1ACYP3A4TGFBR1TGFBR2RET | |
| SCHEMBL1832251 | 0.81 | DYRK1A (0.57) | DYRK1ATGFBR1TGFBR2RETPIK3CA | |
| SCHEMBL30007309 | 0.81 | DYRK1A (0.63) | DYRK1ACYP3A4TGFBR1TGFBR2RET | |
| SCHEMBL14320819 | 0.81 | DYRK1A (0.63) | DYRK1ACYP3A4TGFBR1TGFBR2RET | |
| SCHEMBL30186393 | 0.81 | HSD17B2 (0.47) | HSD17B2HSD17B1CYP3A4CYP2C9PIK3CA | |
| SCHEMBL1576521 | 0.80 | DYRK1A (0.73) | DYRK1ATGFBR1TGFBR2RETPIK3CA | |
| SCHEMBL14826052 | 0.79 | DYRK1A (0.85) | DYRK1ACYP3A4TGFBR1TGFBR2RET | |
| SCHEMBL24529594 | 0.79 | RET (0.61) | DYRK1ATGFBR1TGFBR2RETFYN | |
| SCHEMBL20004011 | 0.78 | ALDH1A3 (0.60) | DYRK1ACYP3A4TGFBR1TGFBR2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12522597-B2 | Methods and compositions for modulating splicing | SKYHAWK THERAPEUTICS, INC. (US) | 2026-01-13 | — | — | US | disclosed |
| US-20230054781-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230054781-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SF3B5 | DYRK1A 4465/4885HSD17B2 2758/4885HSD17B1 2342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.