Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | SLC11A2 | P49281 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499346 | 0.91 | HSD17B1 (0.54) | CYP1A2CYP11B1CYP11B2HSD17B1CNR2 | |
| SCHEMBL2433975 | 0.82 | CYP1A2 (0.60) | CYP1A2CYP11B1CYP11B2HSD17B1GRM5 | |
| SCHEMBL30641498 | 0.79 | MAOA (0.49) | HSD17B1CNR2PTGS2METPDK2 | |
| SCHEMBL28655414 | 0.77 | HSD17B1 (0.78) | CYP1A2CYP11B1CYP11B2HSD17B1GRM5 | |
| SCHEMBL1745161 | 0.76 | HSD17B1 (0.71) | CYP1A2CYP11B1CYP11B2HSD17B1GRM5 | |
| SCHEMBL13680668 | 0.76 | CYP1A2 (0.50) | CYP1A2CYP11B1CYP11B2HSD17B1GRM5 | |
| SCHEMBL14925863 | 0.75 | CYP2A6 (0.41) | PARP10PARP11PTGS2METSLC11A2 | |
| SCHEMBL2448407 | 0.75 | KDM4E (0.49) | CYP1A2CYP11B1CYP11B2HSD17B1GRM5 | |
| SCHEMBL6130756 | 0.74 | PDK2 (0.51) | CYP1A2CNR2HTR1AHTR7PDK2 | |
| SCHEMBL23351094 | 0.73 | CYP11B1 (0.47) | CYP1A2CYP11B1CYP11B2CNR2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10292968-B2 | Substituted heterocycles as bromodomain inhibitors | ZENITH EPIGENETICS LTD. (CA) | 2019-05-21 | — | — | US | disclosed |
| US-20170360756-A1 | SUBSTITUTED HETEROCYCLES AS BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS CORP. (CA) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170360756-A1 | SUBSTITUTED HETEROCYCLES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | CYP1A2 4031/4885CYP11B1 1721/4885CYP11B2 2087/4885 |
| US-10292968-B2 | Substituted heterocycles as bromodomain inhibitors | BRD4, BRD3, BRD1 | CYP1A2 4031/4885CYP11B1 1721/4885CYP11B2 2087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.